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p53(acetyl K370) Antibody

Catalog Number:

HW221
other_names: Antigen NY-CO-13 antibody
BCC7 antibody
Cellular tumor antigen p53 antibody
FLJ92943 antibody
LFS1 antibody
Mutant tumor protein 53 antibody
p53 antibody
p53 tumor suppressor antibody
P53_HUMAN antibody
Phosphoprotein p53 antibody
Tp53 antibody
Transformation related protein 53 antibody
TRP53 antibody
Tumor protein 53 antibody
Tumor protein p53 antibody
Tumor suppressor p53 antibody

Amount:

100μg
calculated_mw: 53 kDa
host_species: Rabbit

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P04637

Form of Antibody:

1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Storage/Stability:

Immunogen:

recombinant protein

Purification:

ProA affinity purified

Specificity/Sensitivity:

Applications:

WB, ICC/IF, IP

Background:

p53, a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation, and cell cycle control mechanisms. p53 localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator, MDM2. MDM2 is an E3 ubiquitin ligase that is upregulated in the presence of active p53, where it poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active DNA-binding conformations and is differentially activated through posttranslational modifications, including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD) of p53, amino acids 110-286, can compromise energetically-favorable association with cis elements and are implicated in several human cancers.

References:

appl_detail:

WB: 1:1,000-1:2,000

ICC: 1:50-1:200

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